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This 31-years old felt a swelling on his arm, for which he had an X-ray and an MRI, which led to a PET/CT and then one failed biopsy. He then came for a repeat biopsy.
The aim was to optimize the biopsy to obtain as much material as possible so that we could get a diagnosis and have adequate material for molecular and genetic studies.
The video below discusses the case, how the biopsy was done and a review of two recent papers on this subject that discuss what factors affect the diagnostic success of a bone biopsy.